Canadian Pharmacist Qualifying Exam Practice · Question
A 68-year-old male presents to the pharmacy with a new prescription for atorvastatin 40 mg daily. He has a history of dyslipidemia, hypertension managed with ramipril, and type 2 diabetes managed with metformin. He is currently taking omeprazole 20 mg daily for GERD. Which of the following drug interactions is most clinically significant for atorvastatin in this patient?
Omeprazole is a strong inhibitor of CYP2C19 and a moderate inhibitor of CYP3A4. Atorvastatin is metabolized primarily by CYP3A4, and co-administration with omep
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Question: A 68-year-old male presents to the pharmacy with a new prescription for atorvastatin 40 mg daily. He has a history of dyslipidemia, hypertension managed with ramipril, and type 2 diabetes managed with metformin. He is currently taking omeprazole 20 mg daily for GERD. Which of the following drug interactions is most clinically significant for atorvastatin in this patient?
Answer options:
- Atorvastatin and Metformin
- Atorvastatin and Ramipril ✅ Atorvastatin and Omeprazole
- Atorvastatin and Grapefruit juice
Correct answer: Atorvastatin and Omeprazole
Explanation: Omeprazole is a strong inhibitor of CYP2C19 and a moderate inhibitor of CYP3A4. Atorvastatin is metabolized primarily by CYP3A4, and co-administration with omeprazole can increase atorvastatin concentrations, increasing the risk of myopathy.
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