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Canadian Pharmacist Qualifying Exam Practice · Question

First-line treatment of anaphylaxis is:

Epinephrine IM is first-line, immediately. Antihistamines and steroids are adjuncts only and do not reverse anaphylaxis. Repeat epi q5–15 min PRN.

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Question: First-line treatment of anaphylaxis is:

Answer options:

  • Oral diphenhydramine ✅ IM epinephrine 0.3–0.5 mg (1:1000) into the anterolateral thigh
  • IV hydrocortisone
  • Salbutamol nebulizer

Correct answer: IM epinephrine 0.3–0.5 mg (1:1000) into the anterolateral thigh

Explanation: Epinephrine IM is first-line, immediately. Antihistamines and steroids are adjuncts only and do not reverse anaphylaxis. Repeat epi q5–15 min PRN.

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