Canadian Pharmacist Qualifying Exam Practice · Question
Which of the following describes a partial agonist?
A partial agonist binds to and activates a given receptor, but has only partial efficacy at the receptor compared to a full agonist, even at high concentrations
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Question: Which of the following describes a partial agonist?
Answer options:
- A drug that binds to and activates a receptor, producing a maximal effect.
- A drug that binds to a receptor but produces no effect, blocking the action of an agonist. ✅ A drug that binds to a receptor and produces a submaximal effect, even when all receptors are occupied.
- A drug that binds to a receptor at a site different from the active site, altering the receptor's activity.
Correct answer: A drug that binds to a receptor and produces a submaximal effect, even when all receptors are occupied.
Explanation: A partial agonist binds to and activates a given receptor, but has only partial efficacy at the receptor compared to a full agonist, even at high concentrations where all receptors are bound.
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