Canadian Pharmacist Qualifying Exam Practice · Question
Which of the following factors would lead to a decreased volume of distribution (Vd) for a highly lipophilic drug?
Increased plasma protein binding would sequester more drug in the central compartment (plasma), making less available to distribute into tissues. This effective
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Question: Which of the following factors would lead to a decreased volume of distribution (Vd) for a highly lipophilic drug?
Answer options: ✅ Increased plasma protein binding.
- Decreased renal function.
- Increased tissue binding.
- Decreased hepatic metabolism.
Correct answer: Increased plasma protein binding.
Explanation: Increased plasma protein binding would sequester more drug in the central compartment (plasma), making less available to distribute into tissues. This effectively decreases the apparent volume of distribution, as a larger fraction of the drug remains in the vascular space.
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