Canadian Pharmacist Qualifying Exam Practice · Question
A drug has a very high first-pass metabolism. Which of the following routes of administration would most likely result in significantly higher systemic bioavailability compared to oral administration?
Sublingual administration allows the drug to be absorbed directly into the systemic circulation via the oral mucosa, bypassing the portal circulation and first-
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Question: A drug has a very high first-pass metabolism. Which of the following routes of administration would most likely result in significantly higher systemic bioavailability compared to oral administration?
Answer options:
- Oral solution ✅ Sublingual tablet
- Rectal suppositories (systemic action)
- Enteric-coated tablets
Correct answer: Sublingual tablet
Explanation: Sublingual administration allows the drug to be absorbed directly into the systemic circulation via the oral mucosa, bypassing the portal circulation and first-pass metabolism in the liver, thus increasing systemic bioavailability.
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