A 75-year-old female with a history of dyslipidemia, hypertension, and a recent lacunar stroke (3 months ago) is currently taking atorvastatin 80 mg daily, ramipril 10 mg daily, and amlodipine 5 mg daily. Her LDL-C is 1.2 mmol/L. She has no history of cardiovascular events prior to the stroke. What is the most appropriate target LDL-C for this patient according to Canadian guidelines?

Question: A 75-year-old female with a history of dyslipidemia, hypertension, and a recent lacunar stroke (3 months ago) is currently taking atorvastatin 80 mg daily, ramipril 10 mg daily, and amlodipine 5 mg daily. Her LDL-C is 1.2 mmol/L. She has no history of cardiovascular events prior to the stroke. What is the most appropriate target LDL-C for this patient according to Canadian guidelines?

Answer options:

• <2.0 mmol/L or 50% reduction from baseline.
• <1.8 mmol/L.
• <1.5 mmol/L. ✅ <1.0 mmol/L and 50% reduction from baseline.

Correct answer: <1.0 mmol/L and 50% reduction from baseline.

Explanation: According to Canadian Cardiovascular Society (CCS) guidelines, patients with a recent ischemic stroke (especially lacunar) are considered very high risk. The target LDL-C for these patients is <1.0 mmol/L and 50% reduction from baseline, to reduce the risk of future cardiovascular events.