Canadian Pharmacist Qualifying Exam Practice · Question
A 72-year-old male, 175 cm tall, weighing 80 kg, with a serum creatinine of 110 µmol/L, is prescribed gabapentin. What is his estimated creatinine clearance (CrCl) using the Cockcroft-Gault equation?
The Cockcroft-Gault equation is: CrCl = [(140 - age) × weight (kg)] / (0.814 × serum creatinine [µmol/L]) for males. For this patient: CrCl = [(140 - 72) × 80]
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Question: A 72-year-old male, 175 cm tall, weighing 80 kg, with a serum creatinine of 110 µmol/L, is prescribed gabapentin. What is his estimated creatinine clearance (CrCl) using the Cockcroft-Gault equation?
Answer options:
- 55 mL/min ✅ 62 mL/min
- 68 mL/min
- 75 mL/min
Correct answer: 62 mL/min
Explanation: The Cockcroft-Gault equation is: CrCl = [(140 - age) × weight (kg)] / (0.814 × serum creatinine [µmol/L]) for males. For this patient: CrCl = [(140 - 72) × 80] / (0.814 × 110) = (68 × 80) / 89.54 = 5440 / 89.54 ≈ 60.75 mL/min. (Note: using ideal body weight is not appropriate here as his current weight is within 20% of his ideal body weight based on height: IBW = 50 + 2.3 * (height in inches - 60) ≈ 70.2-74.8 kg). Rounding to the nearest whole number gives 61 mL/min.
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