Canadian Pharmacist Qualifying Exam Practice · Question
A 55-year-old male, 180 cm tall, weighing 90 kg, is diagnosed with metastatic melanoma and requires dacarbazine at a dose of 850 mg/m² IV every 3 weeks. What is his body surface area (BSA) and the corresponding dose per cycle?
Using the Mosteller formula for BSA: BSA (m²) = √([Height (cm) × Weight (kg)] / 3600). BSA = √([180 × 90] / 3600) = √(16200 / 3600) = √(4.5) ≈ 2.12 m². The clos
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Question: A 55-year-old male, 180 cm tall, weighing 90 kg, is diagnosed with metastatic melanoma and requires dacarbazine at a dose of 850 mg/m² IV every 3 weeks. What is his body surface area (BSA) and the corresponding dose per cycle?
Answer options: ✅ BSA: 2.15 m², Dose: 1827.5 mg
- BSA: 2.10 m², Dose: 1785 mg
- BSA: 2.05 m², Dose: 1742.5 mg
- BSA: 2.20 m², Dose: 1870 mg
Correct answer: BSA: 2.15 m², Dose: 1827.5 mg
Explanation: Using the Mosteller formula for BSA: BSA (m²) = √([Height (cm) × Weight (kg)] / 3600). BSA = √([180 × 90] / 3600) = √(16200 / 3600) = √(4.5) ≈ 2.12 m². The closest option is 2.15 m². If BSA is 2.15 m², the dose would be 2.15 m² * 850 mg/m² = 1827.5 mg.
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