Canadian Pharmacist Qualifying Exam Practice · Question
An elderly patient with renal impairment is prescribed a new medication. Which pharmacokinetic parameter is most likely to be significantly altered?
Renal impairment primarily affects the elimination of drugs, especially those extensively excreted by the kidneys, often requiring dose adjustments. Absorption
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Question: An elderly patient with renal impairment is prescribed a new medication. Which pharmacokinetic parameter is most likely to be significantly altered?
Answer options:
- Absorption
- Distribution
- Metabolism ✅ Elimination
Correct answer: Elimination
Explanation: Renal impairment primarily affects the elimination of drugs, especially those extensively excreted by the kidneys, often requiring dose adjustments. Absorption and distribution are less affected.
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