Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action of statins in treating hyperlipidemia?
Statins work by competitively inhibiting HMG-CoA reductase, an enzyme essential for cholesterol synthesis in the liver, thereby reducing LDL cholesterol.
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Question: What is the primary mechanism of action of statins in treating hyperlipidemia?
Answer options:
- Increasing LDL receptor synthesis ✅ Inhibiting HMG-CoA reductase
- Blocking cholesterol absorption in the intestine
- Activating lipoprotein lipase
Correct answer: Inhibiting HMG-CoA reductase
Explanation: Statins work by competitively inhibiting HMG-CoA reductase, an enzyme essential for cholesterol synthesis in the liver, thereby reducing LDL cholesterol.
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