Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action of metformin in type 2 diabetes?
Metformin primarily works by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues. It does not stimulate insulin secret
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Question: What is the primary mechanism of action of metformin in type 2 diabetes?
Answer options:
- Stimulates insulin secretion from pancreatic beta cells
- Increases glucose uptake by peripheral tissues ✅ Decreases hepatic glucose production
- Inhibits alpha-glucosidase enzymes in the intestine
Correct answer: Decreases hepatic glucose production
Explanation: Metformin primarily works by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues. It does not stimulate insulin secretion directly.
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