Canadian Pharmacist Qualifying Exam Practice · Question
A patient is prescribed a new medication that is a substrate of CYP3A4. What effect would a strong CYP3A4 inhibitor likely have?
A strong CYP3A4 inhibitor would decrease the metabolism of the drug, leading to higher plasma concentrations and an increased risk of toxicity.
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Question: A patient is prescribed a new medication that is a substrate of CYP3A4. What effect would a strong CYP3A4 inhibitor likely have?
Answer options:
- Decreased drug efficacy
- Increased drug clearance ✅ Increased risk of toxicity
- No significant interaction
Correct answer: Increased risk of toxicity
Explanation: A strong CYP3A4 inhibitor would decrease the metabolism of the drug, leading to higher plasma concentrations and an increased risk of toxicity.
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