Canadian Pharmacist Qualifying Exam Practice · Question
Which of the following statements best describes the 'first-pass effect' in pharmacology?
The first-pass effect refers to the extensive metabolism of a drug by the liver and gut wall enzymes after oral administration, reducing the amount of unchanged
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Question: Which of the following statements best describes the 'first-pass effect' in pharmacology?
Answer options: ✅ The metabolism of a drug by the liver before it reaches systemic circulation.
- The initial binding of a drug to plasma proteins.
- The rapid absorption of a drug from the gastrointestinal tract.
- The distribution of a drug to its target receptor site.
Correct answer: The metabolism of a drug by the liver before it reaches systemic circulation.
Explanation: The first-pass effect refers to the extensive metabolism of a drug by the liver and gut wall enzymes after oral administration, reducing the amount of unchanged drug reaching systemic circulation.
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