Canadian Pharmacist Qualifying Exam Practice · Question
A 72-year-old female with chronic kidney disease (eGFR 25 mL/min) is prescribed gabapentin for neuropathic pain. Given that gabapentin is primarily eliminated unchanged by the kidneys, what pharmacokinetic parameter is most significantly altered in this patient?
Gabapentin is excreted almost entirely by the kidneys. In patients with significant renal impairment, the rate of drug elimination is decreased, leading to a pr
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Question: A 72-year-old female with chronic kidney disease (eGFR 25 mL/min) is prescribed gabapentin for neuropathic pain. Given that gabapentin is primarily eliminated unchanged by the kidneys, what pharmacokinetic parameter is most significantly altered in this patient?
Answer options:
- Absorption rate
- Volume of distribution ✅ Elimination half-life
- Protein binding
Correct answer: Elimination half-life
Explanation: Gabapentin is excreted almost entirely by the kidneys. In patients with significant renal impairment, the rate of drug elimination is decreased, leading to a prolonged elimination half-life and potential drug accumulation if doses are not adjusted.
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