Canadian Pharmacist Qualifying Exam Practice · Question
A 7-year-old child requiring a liquid medication has difficulty swallowing. The pharmacist needs to prepare a suspension from crushed tablets. Which property of the drug is most crucial to consider when deciding if it's suitable for suspension preparation?
The solubility of a drug in water is critical when preparing a suspension. A suspension is a heterogenous mixture of insoluble drug particles dispersed in a liq
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Question: A 7-year-old child requiring a liquid medication has difficulty swallowing. The pharmacist needs to prepare a suspension from crushed tablets. Which property of the drug is most crucial to consider when deciding if it's suitable for suspension preparation?
Answer options:
- Half-life
- Protein binding ✅ Solubility in water
- Volume of distribution
Correct answer: Solubility in water
Explanation: The solubility of a drug in water is critical when preparing a suspension. A suspension is a heterogenous mixture of insoluble drug particles dispersed in a liquid medium. If the drug is highly soluble, it would form a solution, not a suspension, or rapidly dissolve, affecting stability.
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