Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action of sartans (e.g., valsartan) in treating hypertension?
Sartans, or ARBs, selectively block the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release.
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Question: What is the primary mechanism of action of sartans (e.g., valsartan) in treating hypertension?
Answer options: ✅ Angiotensin II receptor blockade
- Beta-adrenergic receptor blockade
- Calcium channel blockade
- Direct renin inhibition
Correct answer: Angiotensin II receptor blockade
Explanation: Sartans, or ARBs, selectively block the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release.
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