Canadian Pharmacist Qualifying Exam Practice · Question
A patient with a penicillin allergy requires an antibiotic for a skin infection. Which antibiotic class has the lowest risk of cross-reactivity with penicillin?
Macrolides (e.g., azithromycin) have a distinct chemical structure and mechanism, posing a very low risk of cross-reactivity with penicillin allergies, making t
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Question: A patient with a penicillin allergy requires an antibiotic for a skin infection. Which antibiotic class has the lowest risk of cross-reactivity with penicillin?
Answer options:
- First-generation cephalosporins
- Second-generation cephalosporins
- Carbapenems ✅ Macrolides
Correct answer: Macrolides
Explanation: Macrolides (e.g., azithromycin) have a distinct chemical structure and mechanism, posing a very low risk of cross-reactivity with penicillin allergies, making them a safe alternative.
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