Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action for statin medications?
Statins competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, primarily in the liver.
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Question: What is the primary mechanism of action for statin medications?
Answer options:
- Increase LDL receptor expression ✅ Inhibit HMG-CoA reductase
- Increase triglyceride synthesis
- Promote cholesterol excretion
Correct answer: Inhibit HMG-CoA reductase
Explanation: Statins competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, primarily in the liver.
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