Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism by which sildenafil (Viagra) treats erectile dysfunction?
Sildenafil is a PDE5 inhibitor, which increases cyclic guanosine monophosphate (cGMP) levels in the corpus cavernosum, leading to smooth muscle relaxation and i
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Question: What is the primary mechanism by which sildenafil (Viagra) treats erectile dysfunction?
Answer options: ✅ Inhibiting phosphodiesterase-5 (PDE5) to increase cGMP levels.
- Directly stimulating nitric oxide release.
- Blocking alpha-adrenergic receptors.
- Increasing testosterone production.
Correct answer: Inhibiting phosphodiesterase-5 (PDE5) to increase cGMP levels.
Explanation: Sildenafil is a PDE5 inhibitor, which increases cyclic guanosine monophosphate (cGMP) levels in the corpus cavernosum, leading to smooth muscle relaxation and increased blood flow.
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