Canadian Pharmacist Qualifying Exam Practice · Question
A patient with a penicillin allergy requires antibiotic treatment. Which antibiotic class, despite structural similarities, is generally considered safe for use in patients with a mild penicillin allergy (non-anaphylactic)?
Monobactams (e.g., aztreonam) have a unique monocyclic beta-lactam ring that typically does not cross-react with penicillin antibodies, making them safer for mi
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Question: A patient with a penicillin allergy requires antibiotic treatment. Which antibiotic class, despite structural similarities, is generally considered safe for use in patients with a mild penicillin allergy (non-anaphylactic)?
Answer options:
- First-generation cephalosporins
- Carbapenems ✅ Monobactams
- Second-generation cephalosporins
Correct answer: Monobactams
Explanation: Monobactams (e.g., aztreonam) have a unique monocyclic beta-lactam ring that typically does not cross-react with penicillin antibodies, making them safer for mild penicillin allergies.
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