Canadian Pharmacist Qualifying Exam Practice · Question
A patient presents with symptoms of serotonin syndrome after starting a new antidepressant. Which of the following drug classes, taken concurrently, is most likely to precipitate this interaction?
MAOIs, when taken with other serotonergic drugs, significantly increase serotonin levels, leading to serotonin syndrome. This is a critical drug-drug interactio
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Question: A patient presents with symptoms of serotonin syndrome after starting a new antidepressant. Which of the following drug classes, taken concurrently, is most likely to precipitate this interaction?
Answer options: ✅ Monoamine oxidase inhibitors (MAOIs)
- Beta-blockers
- Thiazide diuretics
- Proton pump inhibitors (PPIs)
Correct answer: Monoamine oxidase inhibitors (MAOIs)
Explanation: MAOIs, when taken with other serotonergic drugs, significantly increase serotonin levels, leading to serotonin syndrome. This is a critical drug-drug interaction.
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