Canadian Pharmacist Qualifying Exam Practice · Question
When counseling a patient on a new prescription for bisphosphonates (e.g., alendronate) for osteoporosis, what is the most important administration instruction?
Proper administration of bisphosphonates is critical to minimize esophageal irritation and ensure adequate absorption.
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Question: When counseling a patient on a new prescription for bisphosphonates (e.g., alendronate) for osteoporosis, what is the most important administration instruction?
Answer options:
- Take with food to minimize GI upset
- Take at bedtime to improve absorption ✅ Take with a full glass of plain water, at least 30 minutes before food or other medication, and remain upright
- Chew the tablet thoroughly before swallowing
Correct answer: Take with a full glass of plain water, at least 30 minutes before food or other medication, and remain upright
Explanation: Proper administration of bisphosphonates is critical to minimize esophageal irritation and ensure adequate absorption.
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