Canadian Pharmacist Qualifying Exam Practice · Question
A patient taking warfarin is prescribed a new antibiotic, trimethoprim/sulfamethoxazole. What is the most important therapeutic consideration?
Trimethoprim/sulfamethoxazole can increase the anticoagulant effect of warfarin, necessitating closer INR monitoring to prevent bleeding. This is a significant
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Question: A patient taking warfarin is prescribed a new antibiotic, trimethoprim/sulfamethoxazole. What is the most important therapeutic consideration?
Answer options:
- Increased risk of hyperkalemia ✅ Enhanced anticoagulant effect leading to bleeding risk
- Reduced efficacy of warfarin due to enzyme induction
- Increased risk of nephrotoxicity
Correct answer: Enhanced anticoagulant effect leading to bleeding risk
Explanation: Trimethoprim/sulfamethoxazole can increase the anticoagulant effect of warfarin, necessitating closer INR monitoring to prevent bleeding. This is a significant drug interaction.
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