Canadian Pharmacist Qualifying Exam Practice · Question
Which of the following medications is most likely to cause a significant increase in serum uric acid levels?
Thiazide diuretics like hydrochlorothiazide are known to cause hyperuricemia by decreasing renal uric acid excretion, which can exacerbate or precipitate gout.
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Question: Which of the following medications is most likely to cause a significant increase in serum uric acid levels?
Answer options:
- Losartan
- Amlodipine ✅ Hydrochlorothiazide
- Metoprolol
Correct answer: Hydrochlorothiazide
Explanation: Thiazide diuretics like hydrochlorothiazide are known to cause hyperuricemia by decreasing renal uric acid excretion, which can exacerbate or precipitate gout.
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