Canadian Pharmacist Qualifying Exam Practice · Question
Which of the following best describes the mechanism of action of metformin?
Metformin primarily works by decreasing glucose production by the liver (gluconeogenesis) and increasing insulin sensitivity in peripheral tissues.
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Question: Which of the following best describes the mechanism of action of metformin?
Answer options:
- Increases insulin secretion from the pancreas.
- Increases glucose uptake by peripheral tissues. ✅ Decreases hepatic glucose production and increases insulin sensitivity.
- Inhibits alpha-glucosidase enzymes in the intestine.
Correct answer: Decreases hepatic glucose production and increases insulin sensitivity.
Explanation: Metformin primarily works by decreasing glucose production by the liver (gluconeogenesis) and increasing insulin sensitivity in peripheral tissues.
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