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Canadian Pharmacist Qualifying Exam Practice · Question

When counselling on a new prescription for levothyroxine, what is the most important instruction regarding administration?

Levothyroxine absorption is significantly affected by food and other medications. Taking it on an empty stomach improves consistency of absorption.

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Question: When counselling on a new prescription for levothyroxine, what is the most important instruction regarding administration?

Answer options:

  • Take it with food to prevent stomach upset.
  • Take it at bedtime to improve absorption. ✅ Take it on an empty stomach at least 30-60 minutes before breakfast.
  • It can be taken at any time of day, as long as it's consistent.

Correct answer: Take it on an empty stomach at least 30-60 minutes before breakfast.

Explanation: Levothyroxine absorption is significantly affected by food and other medications. Taking it on an empty stomach improves consistency of absorption.

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