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Canadian Pharmacist Qualifying Exam Practice · Question

Which of the following is a common adverse effect of opioid analgesics that patients often develop tolerance to over time?

Patients commonly develop tolerance to the sedative effects of opioids relatively quickly. Constipation, however, tends to be a persistent side effect.

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Question: Which of the following is a common adverse effect of opioid analgesics that patients often develop tolerance to over time?

Answer options:

  • Constipation
  • Respiratory depression
  • Miosis ✅ Sedation

Correct answer: Sedation

Explanation: Patients commonly develop tolerance to the sedative effects of opioids relatively quickly. Constipation, however, tends to be a persistent side effect.

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