Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action of sacubitril/valsartan in heart failure?
Sacubitril/valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI) that improves outcomes in heart failure by blocking angiotensin II effects and incre
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Question: What is the primary mechanism of action of sacubitril/valsartan in heart failure?
Answer options: ✅ Angiotensin receptor and neprilysin inhibition
- Beta-adrenergic receptor blockade
- Direct renin inhibition
- Sodium-glucose cotransporter 2 inhibition
Correct answer: Angiotensin receptor and neprilysin inhibition
Explanation: Sacubitril/valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI) that improves outcomes in heart failure by blocking angiotensin II effects and increasing natriuretic peptides.
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