Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action of ACE inhibitors in managing hypertension?
ACE inhibitors block the conversion of angiotensin I to angiotensin II, leading to vasodilation, reduced aldosterone secretion, and decreased blood pressure.
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Question: What is the primary mechanism of action of ACE inhibitors in managing hypertension?
Answer options: ✅ Inhibition of angiotensin-converting enzyme, leading to reduced angiotensin II and aldosterone.
- Blocking of beta-adrenergic receptors, reducing heart rate and cardiac output.
- Direct relaxation of vascular smooth muscle, causing vasodilation.
- Increased excretion of sodium and water by the kidneys.
Correct answer: Inhibition of angiotensin-converting enzyme, leading to reduced angiotensin II and aldosterone.
Explanation: ACE inhibitors block the conversion of angiotensin I to angiotensin II, leading to vasodilation, reduced aldosterone secretion, and decreased blood pressure.
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