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Canadian Pharmacist Qualifying Exam Practice · Question

When counseling a patient newly prescribed methotrexate for rheumatoid arthritis, what is a key safety message?

Methotrexate is hepatotoxic, and concomitant alcohol consumption significantly increases the risk of liver damage. Patients must be strongly advised to avoid al

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Question: When counseling a patient newly prescribed methotrexate for rheumatoid arthritis, what is a key safety message?

Answer options: ✅ Avoid alcohol completely due to liver toxicity risk

  • Take with dairy products to improve absorption
  • It can be stopped abruptly if side effects occur
  • Expect immediate pain relief within a few days

Correct answer: Avoid alcohol completely due to liver toxicity risk

Explanation: Methotrexate is hepatotoxic, and concomitant alcohol consumption significantly increases the risk of liver damage. Patients must be strongly advised to avoid alcohol.

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