Canadian Pharmacist Qualifying Exam Practice · Question
Which of the following factors would most likely lead to a higher dose requirement for warfarin?
Vitamin K is a cofactor for the synthesis of clotting factors that warfarin inhibits. High dietary intake of vitamin K can reduce warfarin's anticoagulant effec
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Question: Which of the following factors would most likely lead to a higher dose requirement for warfarin?
Answer options: ✅ High dietary intake of vitamin K
- Concurrent use of amiodarone
- Liver dysfunction
- Advanced age
Correct answer: High dietary intake of vitamin K
Explanation: Vitamin K is a cofactor for the synthesis of clotting factors that warfarin inhibits. High dietary intake of vitamin K can reduce warfarin's anticoagulant effect, requiring a higher dose.
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