Canadian Pharmacist Qualifying Exam Practice · Question
What is the primary mechanism of action for statin medications in lowering cholesterol?
Statins competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, leading to reduced cholesterol production.
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Question: What is the primary mechanism of action for statin medications in lowering cholesterol?
Answer options: ✅ Inhibiting HMG-CoA reductase
- Increasing LDL receptor expression
- Binding to bile acids in the gut
- Activating lipoprotein lipase
Correct answer: Inhibiting HMG-CoA reductase
Explanation: Statins competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, leading to reduced cholesterol production.
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