Canadian Pharmacist Qualifying Exam Practice · Question
A patient taking warfarin is starting a new antibiotic. Which antibiotic class carries the highest risk of significantly increasing INR and bleeding risk?
Macrolide antibiotics, particularly clarithromycin, can inhibit warfarin metabolism, leading to increased INR and bleeding risk.
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Question: A patient taking warfarin is starting a new antibiotic. Which antibiotic class carries the highest risk of significantly increasing INR and bleeding risk?
Answer options: ✅ Macrolides (e.g., clarithromycin)
- Tetracyclines (e.g., doxycycline)
- Cephalosporins (e.g., cephalexin)
- Penicillins (e.g., amoxicillin)
Correct answer: Macrolides (e.g., clarithromycin)
Explanation: Macrolide antibiotics, particularly clarithromycin, can inhibit warfarin metabolism, leading to increased INR and bleeding risk.
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