Canadian Pharmacist Qualifying Exam Practice · Question
Combining an SSRI with an MAOI risks:
Symptoms: hyperthermia, agitation, clonus, hyperreflexia, autonomic instability. Wash-out 14 days between MAOI and SSRI (5 weeks for fluoxetine).
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Question: Combining an SSRI with an MAOI risks:
Answer options: ✅ Serotonin syndrome
- Constipation
- Hypoglycemia
- Anemia
Correct answer: Serotonin syndrome
Explanation: Symptoms: hyperthermia, agitation, clonus, hyperreflexia, autonomic instability. Wash-out 14 days between MAOI and SSRI (5 weeks for fluoxetine).
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